Journal: The Journal of Physiology

Article Title: Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria

doi: 10.1113/jphysiol.2013.254987

Figure Lengend Snippet: Regional proportional APD 90 properties in the models and experiment

Article Snippet: Experimental and clinical evidence have suggested that: (1) atrial tissues with large regional differences in electrical properties are more susceptible to re-entry ( Allessie et al. 1976 ; Spach et al. 1989 ); (2) re-entrant wavelets propagating in an abnormal atrial tissue substrate can sustain high-frequency irregular electrical activity in AF ( Harada et al. 1996 ; Jalife et al. 2002 ; Nattel et al. 2005 ); (3) ‘driver’ regions acting as the dominant frequency sources during AF may be located in the LA near the PV sleeves, whereas the RA is characterised by multiple wavelets ( Haïssaguerre et al. 1998 ; Chen et al. 1999 ; Sanders et al. 2005 ); (4) rapid AF is also often progressive, going from paroxysmal to chronic, with electrical and structural remodelling of the atria leading to a substrate that facilitates self-perpetuation of the arrhythmia ( Nattel et al. 2005 ; Anter et al. 2009 ).

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